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1 ( ) *. :. :... / / / / : (P=/) (P=/). (P=/) AST (P=/) ALT (P=/) (P =/) (P</)...(R=/) :. : // : // : * sdmoghaddam@yahoo.com

2 / NAFLD.( )...().() ).(.( ). 5. Tumor Necrosis Factorα (TNFα) (NAFLD) (NASH)..() NASH.().() NASH.()..( ) ( ) ( ) 1 NonAlcoholic Fatty Liver Disease 2 Simple Steatosis 3 Non Alcoholic Steatohepatitis 4 Obese 5 Morbid Obesity

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5 / / P.. / ( ) /±/..( ) (Inc, Chicago, IL SPSS) SPSS.. T U ( ρ * ٠/٠٠١ ٣٨/۴±١٠/٣ ۴٢/٣ ± ١٠/۵٠ ٣۵/۶١±٩/٢ () <٠/٠٠١ <٠/٠٠١ ٠/١٣١ ٠/٩۶٧ ٠/۴٠١ ٠/۴٠۶ ٠/٧١٧ ١۶٧/٣±١٠/٢ ٨۴/٠۵±١۴/٧ ٢٩/٩±۴/۴ ٩۶/٠٣±١٧/٢ ٩٩±١٨/٣ ١/٢۵±٠/٧٨ ١٣/۴۴±٣/٠٨ ١۵٧/٠٢±۴/۶ ٧۵/۶±١٢/٢ ٣٠/٧±۴/٩ ٩۵/٩±١٢/٧ ١٠٠/٨±٢٢/۴ ١/١٨±٠/٨۴ ١٣/٣١±٣/١ ١٧۴/٨±۵/۶ ٩٠/٠٩±١٣/٣ ٢٩/٣±۴ ٩۶/٠٩±١٩/٩ ٩٧/٧±١۴/٧ ١/٣١±٠/٧۴ ١٣/۵٣±٣/١٧ (cm) (kg) (kg/m2) (cm) (mg/dl) (mm) / P* (/ P=/) (/ P=/) (/ P=/). AST) (ALT.( ) ( /) : /) ( /).( / ) ( P</) (/

6 / NAFLD ( ρ / / / </ / / / / / / / / / / /±/ /± /±/ ±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ /± /±/ /±/ /±/ ±/ /±/ /± /±/ /±/ /±/ /±/ /±/ /± /±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ /±/ ±/ /±/ /±/ /±/ /±/ /± /±/ /±/ /± /±/ /±/ () () () () ( ) () ( )HDL ( )LDL ( )AST ( )ALT ( )Alk P ( ) Alkaline phosphatase:alk P, non significant: alanine aminotransferase,:alt, aspartate aminotransferase:ast, Low density lipoprotein:ldl,high density lipoprotein:hdl.( ).(R=/) ( *ρ / / / / / / / / / / / / / *P. P</) (/ (/ P</) (/ P</) (/ p=/) P=/) P</) (/ (/ LDLHDL ALT AST

7 / /.( ).() α.( ) α.().(). ) (.().().().()..( ).().() ( )..().( ). 9 Portal 10 Nonportal

8 / NAFLD..().. ().() ( ) ()..() ().. References: 1.Mills SJ, Harrison SA. Comparison of the natural history of alcoholic and nonalcoholic fatty liver disease. Curr Gastroenterol Rep 2005; 7: Sanyal AJ. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology 2002; 123: Caballeria L, Auladell MA, Toran P, et al. Risk factors associated with nonalcoholic fatty liver disease in subjects from primary care units. A casecontrol study. BMC Gastroenterol 2008; 8: Marchesini G, Marzocchi R. Metabolic syndrome and NASH. Clin Liver Dis 2007;

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