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2 ! # %& ()%+! # % & ()+,./01+234/5/ /.6/./3:;6<(=> (? %Α&6./ 6/.6..2! # %&& ()&+,) +./ +0&%)1./ (&/ 2 3 %& /& &.# &41.+5&% &.# #%.+,2&%.+( 2/0)( 2/ 6 Simon J. Rees* a, Miaomiao He a, +./ ( 0 +#1+2/ &34+,/5+60,(/,78 +9 : 8#; / <+9 +=#/ 1#& +>/(: &( 4<+? () &<+> Α+ Β=??(&Χ=+)%+< > =?4 Ε% =+Φ((&&;?((&Γ) 6ΗΑ6 Ι 9+&>%> >(=ϑκ+(?<λη+)ε &>Η%+Η# (7(Μ( =Χ (+>Ν7(Ο=+>ϑ=?>Π+%Μ(?&%>ΛΝΘ (ΡΗ>(ΣΗΛΝ Τ(%Α(&>(?ΝΤΚ/ΥςΩΝΠΞ6Ψ22,.1//3 Ζ[[Υ[3 Ξ(ΛΣ=?)&4#=?( = ( (Η>( Α Η+<(?]+ (?%ΑΗ =)( ΝΑ=+) Α>%=+Νϑ %)ϑ =Σ /

3 ! # %& ()%+! # % & ()+,./01+234/5/ /.6/./3:;6<(=> (? %Α&6./ 6/.6..2! # %&& ()&+,) +./ +0&%)1./ (&/ 2 3 %& /& &.# &41.+5&% &.# #%.+,2&%.+( 2/0)( 2/ 6!3,#%.1# Β= =+ΗΧΧ?=ΗΑ (&>=> (&% Η>%=+=ϑς=?( = (Ω(Η>Κ Α Η+<(?&Η&& ( (Η> >?Η+&ϑ(?Σ%> %+> (Α%?Α Η>%+<ϑ %)Η+)<?= >>=#(%+Η Η&%5&>(Η)Λ&>Η>(Η+)%<+=?( Η %Η Α=+) Α>%=+ (Η>>?Η+&ϑ(?6Θ %&ΧΗΧ(?Χ?(&(+>&Η+ (?%ΑΗ =)( > Η>%&>?((5 )% (+&%=+Η Ν%+Α )(&( Χ %Α%>?(Χ?(&(+>Η>%=+&=ϑ> (Α%?Α Η>%+<ϑ %)Η+)=> (?#=?( = ( Α= Χ=+(+>&ΝΗ+)&=Η =Σ&ΑΗ Α Η>%=+=ϑ)Λ+Η %Α#( ΗΜ%=?&=Μ(?& =?>Η+) =+< >% (&ΑΗ (&6Θ ( =)( %&ϑ=? Η>() &%+<Ηϑ%+%>(Μ= (ΗΧΧ?=ΗΑ &%+< >%5# =ΑΙ (& (&>=?(Χ?(&(+>> (<?= +)ΝΧ%Χ(&Νϑ %)Η+)<?= >%+Η<(= (>?%ΑΗ ΛΑ=??(Α> Η++(?6_Η %)Η>%=+Η+)Μ(?%ϑ%ΑΗ>%=+( (?Α%&(&Η?(Χ?(&(+>()> Η> &(#=> & =?> >% (&ΑΗ ()Η>Η>=%)(+>%ϑΛ>?Η+&Χ=?>)( ΗΛ(ϑϑ(Α>&ΝΗ+) =+<>% (&ΑΗ ()Η>Η>=( Η %+(> ( =)( %+<=ϑ&(η&=+η (Η>>?Η+&ϑ(?Η+)& =Σ> ( =)( %&ΑΗΧΗ# (=ϑχ?()%α>%+<= > (> >( Χ(?Η>?(&Η+) (Η>>?Η+&ϑ(??Η>(&ΗΑΑ?Η>( Λ6 > =+<>% (&ΑΗ (&#=?( = ( (Η> >?Η+&ϑ(?&(( &Σ( Α Η?ΗΑ>(?% ()#Λ> ( (Η+ϑ %)Η+)#=?( = (ΣΗ >( Χ(?Η>?(%ϑ > (ϑ %)Α%?Α Η>%+<Μ( =Α%>Λ%&?(Η&=+Η# Λ %< # >Η> =Σ(?ϑ =Σ?Η>(&> %&%&+=>> ( ΑΗ&(6Ε> )Λ=ϑ> (& =?>>% (&ΑΗ ()Λ+Η %Α& Η&& =Σ+> Η>+=+ %+(Η?%>%(&%+> ( >( Χ(?Η>?(Η+) (Η>ϑ Χ?=ϑ% (&Η?(+=>%Α(Η# (=Μ(?> (Σ = (Μ( =Α%>Λ?Η+<(=ϑ Χ?ΗΑ>%ΑΗ %+>(?(&>6Θ (% Χ=?>Η+Α(=ϑ?(Χ?(&(+>%+<> (> (? Η Η&&=ϑ> (<?= >Η+)> ( )Λ+Η %ΑΜΗ?%Η>%=+&%+>( Χ(?Η>?(<?Η)%(+>Η&Σ( Η&> (ϑ %)>?Η+&Χ=?>Σ%> %+> ( #=?( = ( Η&#((+ %< %< >()69 Χ %ΑΗ>%=+&ϑ=?&% Χ %ϑ%() =)( %+<ΗΧΧ?=ΗΑ (&Η?( Η &=)%&Α &&()6 7 &+1/.#0%& Β Χ &Χ(Α%ϑ%Α (Η>,Ια:Ι<6Ξ1 9+ )%Η (>(?, 1 2 ΚΗ&> Α( ϑηα(ϑ,β: 1+ +%+ Α=+Μ(Α>%=+ (Η>>?Η+&ϑ(?Α=(ϑϑ%Α%(+>,β: 6Ξ1?+ (+<>, 1! &?ϑηα(+=? Η Μ(Α>=?,51 Χ!=%+>,%+ (& 1 Ε (Η>>?Η+&ϑ(??Η>(Χ(? +%> (+<>,β: 1 &+?Η)% &, 1 Φ > (? Η?(&%&%>Η+Α(, 6Ξ:β1+ &?ϑηα(η?(η, 1 ++ >% (,&1+ Γ+ >( Χ(?Η>?(,χΒ1 # &?ϑηα(μ( =Α%>ΛΜ(Α>=?, :&1

4 ! # %& ()%+! # % & ()+,./01+234/5/ /.6/./3:;6<(=> (? %Α&6./ 6/.6..2 vɺ+ Μ= (ϑ =Σ?Η>(, 0 :&1 Μ= (, 0 1!& Η+64 7#8 Ι+ > (? Η )%ϑϑ &%Μ%>Λ, :&1+ ϑ+ =ΑΗ Α==?)%+Η>(&, 1 Κ+ )(+&%>Λ,Ι<: 0 1 Λ > (? Η Α=+) Α>%Μ%>Λ,β: 6Ξ1!!!# %&!(%!)+,%& + #.+ 07)&(; + % Α( %+)( + (Η&>+ Μ+ Σ(&>+ /+ +=?> + + &= > + + >=Χ+ 7+ #=>>= + 0; &)&(; + +Β+ Α=+Μ(Α>%=+ 9 )%ϑϑ &%=+ /+ Α=+Μ(Α>%=+Α=??( Η>%=+( Χ=+(+> Ν0 7 &+ Ν0 δ &&( >+ #(? Φ Φ(Λ+= )&+ #(? Χ&!?Η+> + #(? Ο)&#/4 + ςωκ ς=?( = (Ω(Η>Κ Α Η+<(? ς%βρεθ ς ς%5α=+; <Η>(<?Η)%(+>&>Η#% % ()&= Μ(? Β ΦΟ ΒΗΧΗΑ%>Η+Α(Φ(&%&>Η+Α(Ο=)( Βε7 Β= Χ >Η>%=+Η ε %)7Λ+Η %Α& 7ΕΘ 7 Α>Ε>=?Η<( =)( ΚβΕ Κ?)Σφ? (&=+)(+ ΡΚΟΕ07 Ρ(+(?Η Κ ΛΧ>%ΑΗ Ο %>5# =ΑΙΕ= Μ(?07 Ω_ Β Ω(Η>%+<_(+>% Η>%=+Η+) %?5Α=+)%>%=+%+< ΦΟΕΚ Φ==>Ο(Η+Ε Η?(Κ??=? ΦΘ7 Φ(&%)(+Α(>% ()%&>?%# >%=+ ΘΦΒΟ Θ (? Η Φ(&%&>Η+Α(ΒΗΧΗΑ%>Η+Α(Ο=)( ΘΦδΕγΕ Θ?Η+&%(+>ΕΛ&>( &% Η>%=+>== ΘΦΘ Θ (? Η Φ(&Χ=+&(Θ(&>%+< 89 :+#% (01#) + Ε%+< (ΧΗ%?&=ϑΧ%Χ(&ϑ=? ()%+ΗηΠι ==ΧΗ+)<?= >()%+>=Μ(?>%ΑΗ #=?( = (&Η?( Χ?=#Η# Λ> (Α= =+(&>ϑ=? =ϑ<?= +) (Η>( Α Η+<(?ϑ= +)%+Ρ?= +)Ε=?Α(Ω(Η>! Χ&Λ&>( &ΝΗ+)Η?(Ι+=Σ+Η&ς=?( = (Ω(Η>Κ Α Η+<(?&,ςΩΚ&16Θ (Α= Χ=+(+>&=ϑ 0

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9 ! # %& ()%+! # % & ()+,./01+234/5/ /.6/./3:;6<(=> (? %Α&6./ 6/.6..2 ( Χ %Α%> Λ?(Χ?(&(+>()# >Η?( % %>()%++=>#(%+<Η# (>=ΑΗ Α Η>(Η %Η (Η>>?Η+&ϑ(? = >&%)(> (#=?( = (Η+) (+Α(+=>Η# (>=?(Χ?(&(+>Η =+<>% (&ΑΗ ((ϑϑ(α>&6 β (?(>?((5)% (+&%=+Η + (?%ΑΗ =)( & ΗΜ(#((+ΗΧΧ %()Ν> (%+>(?(&> Η& =&> Λ#((+%+&> )Λ%+< =+<>% (Η+)&ΧΗ>%Η &ΑΗ (&Νϑ=?( Η Χ (Ν%+>(?ΗΑ>%=+%+ Η?<(? #=?( = (Η??ΗΛ&Ν (>(?=<(+(= &<?= +)Χ?=Χ(?>%(&=?> ((ϑϑ(α>&=ϑ<?= +)ΣΗ>(?ϑ =Σ69+ Μ%(Σ=ϑ> (Α= Χ >Η>%=+Η )( Η+)&=ϑ& Α (> =)&ΝΗ+ #(?=ϑηχχ?=ηα (& ΗΜ(#((+ Χ?=Χ=&()>=?() Α(> ()%&Α?(>% Η>%=+=ϑ> (#=?( = (Α= Χ=+(+>&6 5Ξ =?Λ +,8Α,..ΖΝ..31)(Μ( =Χ()Η&Χ(Α%Η /7 (Η>Χ%Χ(ϑ%+%>(( ( (+>> Η>Α=+&%)(?()> (Χ%Χ( ϑ =Σ&Η+)Α=+) Α>%=+%+> (<?= > Η>(?%Η &%+<Η&%+< (( ( (+>6Θ (#=?( = (ϑ%( )&=ϑ %+>(?(&>Σ(?()%&Α?(>% () &%+<ΗΜ(?>%ΑΗ %+(=ϑ& Α ( ( (+>&Α= Χ ()>=&??= +)%+< 07( ( (+>&6 Μ(?Λ&% % Η?ΗΧΧ?=ΗΑ ΣΗ&)(Μ( =Χ()#Λ7%(?&Α +,8Α,.//1>= %+>(<?Η>(ΗςΩΚ%+ΗΑ= (?Α%Η ϑ%+%>(( ( (+>&=ϑ>ση?(χηαιη<(η+)&% % Η? ΛΝ Ε%<+=?( % +,8,..[16Ο=>>Η< ΛΗ+)7%;Ι& ==?+,./ 1 ΗΜ(>ΗΙ(+Η&% % Η?ΗΧΧ?=ΗΑ ( Α(Χ>> Η>> (#=?( = (%&?(Χ?(&(+>()#ΛΗϑ%+%>()%ϑϑ(?(+Α( =)( Α= Χ ()>=> (07 ϑ%+%>(( ( (+>&= Μ(?6Β % +,8Α,..κ1 &()ΗΑ= (?Α%Η ϑ%+%>(( ( (+>&= Μ(?# > )%&Α?(>% ()> (<?= >Η+)Χ%Χ(&Σ%> Η?( Η>%Μ( Λϑ%+( (& =ϑ07( ( (+>&6 > = < > (%?>?(Η> (+>=ϑ> (ϑ %)%&+=>ϑ Λ)(&Α?%#()> (Χ?()%Α>%=+&=ϑ (Η>>?Η+&ϑ(??Η>(& Η+)Χ%Χ(ΣΗ >( Χ(?Η>?(Α= ΧΗ?()ϑΗΜ=?Η# ΛΣ%> & =?>>% (&ΑΗ (( Χ(?% (+>Η (Η&?( (+>&6 8+(ΗΧΧ?=ΗΑ >= =)( %+<ςωκσ%> > (Η% =ϑαηχ>?%+<η > (Χ Λ&%ΑΗ (ϑϑ(α>& +=>()(Η? %(?Ν%&>= &(Η>?(()% (+&%=+Η + (?%ΑΗ =)( > Η>)%&Α?(>% (&> ( #=?( = (Α= Χ=+(+>&Η+)%+Α )(&Η)%&Α?(>()Λ+Η %Α =)( =ϑ> (Α%?Α Η>%+<ϑ %)6 Θ %&%&> (ΗΧΧ?=ΗΑ >ΗΙ(+%+> (Σ=?Ι?(Χ=?>() (?(6Θ?((5)% (+&%=+Η =)( & ΗΜ( > (Η)ΜΗ+>Η<(> Η>)Λ+Η %Αϑ %)>?Η+&Χ=?>Η =+<> (Χ%Χ( ==ΧΑΗ+#(?(Χ?(&(+>() ( Χ %Α%> ΛΗ+)>( Χ(?Η>?(ΜΗ?%Η>%=+&ΗΑΑ=?)%+<>=)(Χ> ΑΗ+#( =)( ()69+Η))%>%=+Ν )%ϑϑ(?(+> ΗΛ(?&=ϑ?=ΑΙΗ+)&=% ΑΗ+#(( Χ %Α%> Λ?(Χ?(&(+>()Η+)Α % Η>()(Χ(+)(+> #= +)Η?ΛΑ=+)%>%=+&Η>> (&?ϑηα(αη+#(ηχχ %()6ε?> (? =?(Ν (Η>>?Η+&ϑ(?#( =Σ> ( #=?( = (Η??ΗΛΑΗ+#(( Χ %Α%> ΛΑ=+&%)(?()Η+)%+%>%Η Μ(?>%ΑΗ <?= +)>( Χ(?Η>?( <?Η)%(+>&ΑΗ+#(% Χ=&()6 Θ?((5)% (+&%=+Η =)( &=ϑϑ(? =&><(+(?Η %>ΛΗ+)Χ=>(+>%Η Λ =&>ΗΑΑ?Η>(?(Χ?(&(+>Η>%=+=ϑ (Η>>?Η+&ϑ(?# > ΗΜ(> ()%&Η)ΜΗ+>Η<(> Η>Α=+&%)(?Η# (Α= Χ >%+<?(&=?Α(&Η?(?( %?()ϑ=?>?η+&%(+>&% Η>%=+=Μ(?( >(+)()>% (&ΑΗ (&6Θ ( =)( κ

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11 ! # %& ()%+! # % & ()+,./01+234/5/ /.6/./3:;6<(=> (? %Α&6./ 6/.6..2 Θ (ε%+%>(_= (Ο(> =) Η&#((+ &()>=)%&Α?(>% (> (%+>(<?Η ϑ=? =ϑ> ( Α=+Μ(Α>%=+5)%ϑϑ &%=+>( Χ(?Η>?(( Η>%=+6Θ (ΗΧΧ?=ΗΑ >=)(Η %+<Σ%> +=+5 =?> =<=+Η Α( <(= (>?%(& Η&#((+>=)%&Α?(>% (> (( Η>%=+%+Χ Λ&%ΑΗ &ΧΗΑ( &%+<Η+ ΗΧΧ?=ΗΑ &% % Η?>=> Η>)(&Α?%#()#Λε(? %<(?Η+)!(?%Α,.. 16Θ (Χ?% Η?ΛΜΗ?%Η# (& Η?()(ϑ%+()Η>> ( ( Η ()?Η Α( Α(+>?=%)&=+Η# =ΑΙ5&>? Α>?() (& 6Θ (%+>(<?Η ϑ=? =ϑ> (Α=+Μ(Α>%=+5)%ϑϑ &%=+( Η>%=+&= Μ() (?(, (ΗΜ%+<Η&%)(&=?Α(>(? &1%&4!!!!!!!!!!!!!!!!!!!!!!!!!!,/1!! β(( Χ Η%+> ()(&Α?(>% Η>%=+=ϑ> (Α=+Μ(Α>%Μ(Η+))%ϑϑ &%Μ(ϑ >(? &&(ΧΗ?Η>( ΛΗ& ϑ= =Σ&6Θ (Η)Μ(Α>%=+ϑ >(? %+)%&Α?(>(ϑ=? %&ΗΧΧ?= % Η>()#Λ> (& =ϑ> ( Α=+Μ(Α>%=+,Η)Μ(Α>%=+1ϑ (&>?= < (ΗΑ Α( ϑηα(& Α > Η>Ν!!!!!!!!!!!!!!, 1 Σ (?(Ν%ο+Ν&ΝΣΝ(Ν>Ν#ϑ=?Η ( Η ()?Η Α( 6 && %+<> (ϑ ΑΗ+#(?(Χ?(&(+>()#Λ> ( ΜΗ (&=ϑ>( Χ(?Η>?(Η+)Μ( =Α%>ΛΗ>> (Α( ϑηα(α(+>?=%)νσ(αη+ &(> (ϑηα(η?(ηη+) +=? Η Μ(Α>=?>= ΗΙ(> (&(Α=+)=?)(?ΗΧΧ?= % Η>%=+Ν!!!!!!!!!!!!!!!,01 9+> %&ΧΗ?>%Α Η?% Χ ( (+>Η>%=+=ϑ> ( (Η>( Α Η+<(? =)( > (Α=+Μ(Α>%=+,Η)Μ(Α>%=+1ϑ >(? %&=+ Λ &()ϑ=?&% Η>%+<> (ϑ %)ϑ =Σ&%+> (Χ%Χ(&Η+)=+ Λ> ( Μ( =Α%>Λ%+> ()=Σ+ΣΗ?)Η+) ΧΣΗ?))%?(Α>%=+&%+> (Η&&=Α%Η>()Α( &%&+=+5 (?=6 <Η%+ΝΗ&& %+<> Η>> (ΜΗ (=ϑ> (>( Χ(?Η>?(Γ=Μ(?ΗΧΗ?>%Α Η?ϑΗΑ(%&Σ(?(Χ?(&(+>()#Λ> (ΜΗ (Η>> (ϑηα(α(+>?=%)ν> ()%ϑϑ &%=+ (Η>ϑ ΑΗ+#( ΗΧΧ?= % Η>()Η&!!!!!!!!!!!!!!!!!!!!!!!!,21 Θ %&?( %?(&Η)%&Α?(>( (> =)ϑ=?ϑ%+)%+<> (<?Η)%(+>=ϑ> (>( Χ(?Η>?(,!!1 Η>(ΗΑ Α( ϑηα( &%+<> (Α( Α(+>?=%)ΜΗ (&6 >ΛΧ%ΑΗ +=+5=?> =<=+Η Α( ΝΣ%> =ΑΗ Α==?)%+Η>(&Η>> ((Η&>Α( ϑηα(ν%&% &>?Η>()%+ε%<6 6Θ (Α==?)%+Η>(/%&)(ϑ%+()%+> ( /.

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13 ! # %& ()%+! # % & ()+,./01+234/5/ /.6/./3:;6<(=> (? %Α&6./ 6/.6..2 Η =Σ&Η)(<?((=ϑΧΗ?Η ( Χ?=Α(&&%+<#Λ> (&= Μ%+<> (( Η>%=+&=ϑ(ΗΑ # =ΑΙΣ%> &(ΧΗ?Η>(>?(Η)&6 ;9; <&, 5&+&%.#) + Θ (#=?( = ( (Η>( Α Η+<(?<(= (>?Λ Η&#((+)%&Α?(>% () &%+<Η>?((5)% (+&%=+Η >%5# =ΑΙ#= +)Η?Λϑ%>>()&>? Α>?() (& Η+)> %& Η&#((+)(ϑ%+() &%+<Η+%+5 = &( >% %>Λ,Φ((&Ν..Υ1> Η> &(&Η>Σ=5)% (+&%=+Η )(ϑ%+%>%=+=ϑ> (#=?( = ( Α= Χ=+(+>&Η+)( >? )(&> %&>=ϑ=? Η07 (& & Α Η&> Η>& =Σ+%+ε%<6069+)%Μ%) Η # =ΑΙ&)(ϑ%+(> (Χ%Χ(&Η+)>Σ=# =ΑΙ&Η?( &()>=)(ϑ%+(> (<?= > Η>(?%Η Σ%> %+> ( #=?( = (6Ο >%Χ (# =ΑΙ& ΗΛ#( &()>=)(ϑ%+(> (&??= +)%+<<?= +))(Χ(+)%+<=+ > (ϑη?ϑ%( )#= +)Η?Λ& ΗΧ(Η+)Η &=ϕ#λ?(χ(η>%+<&% % Η?#=?( = (# =ΑΙ Η??Η+<( (+>&ϕη);ηα(+>#=?( = (&69+> %&ΧΗΧ(?=+ ΛΗ&%+< (#=?( = (%&&> )%()Η+)Η &( %5Α%?Α Η?ϑΗ?ϑ%( )#= +)Η?Λ%&& ϑϑ%α%(+>6, ΧΧ %ΑΗ>%=+&Σ%> >%5#=?( = ( (& (& Η?()(&Α?%#()%+Ω(Ν./ 16Β=Η?&(Η+)ϑ%+(#=?( = ( (& (&Η?(% &>?Η>()%+ε%<626 Θ (ϑ %)Α%?Α Η>%+<%+> (Π5> #(%&?(Χ?(&(+>()Η&Η&%+< ( ΗΛ(?=ϑΑ( &%+> ( (& Η);ΗΑ(+>>=> (%++(?Χ%Χ(&?ϑΗΑ(&6Θ %&%&Η > Η>%&?( %?()>=% Χ ( (+>Ηϑ Λ Α= Χ ()=+(5)% (+&%=+Η =)( =ϑ> (ϑ %)>?Η+&Χ=?>6Θ (> (? Η ΑΗΧΗΑ%>Λ=ϑ> (&( Α( &%&Η); &>()&=> Η>> (ϑ %) Η&&=ϑ> (Σ = (Χ%Χ(%&>ΗΙ(+%+>=Α=+&%)(?Η>%=+6Θ ( %+ (>#= +)Η?ΛΑ=+)%>%=+%&)(ϑ%+()#Λ> (Μ( =Α%>ΛΗ+)>( Χ(?Η>?(Η>> (Α( ϑηα(&η> > (>=Χ=ϑ> (Χ%Χ(Η+)> (ϑ %)Μ( =Α%>Λ%&% Χ=&()%+(ΗΑ Α( Η =+<> ( (+<> =ϑ> ( Χ%Χ(&ΗΑΑ=?)%+<>=> (>% (ΜΗ?Λ%+< Η&&ϑ =Σ?Η>(6Θ %&ΗΧΧ?=ΗΑ Η = +>&>=Η=+( )% (+&%=+Η?(Χ?(&(+>Η>%=+=ϑ> (ϑ %)ϑ =Σ6Θ ( % %>Η>%=+&=ϑ> %&ΗΧΧ?= % Η>%=+Η?( )%&Α &&() Η>(?6 Ω(Η>>?Η+&ϑ(?#ΛΑ=+) Α>%=+Σ%> %+> (Α%?Α Η>%+<ϑ %)%&+=>&%<+%ϑ%αη+> Α= ΧΗ?()>=> (Α=+Μ(Α>%=+Χ?=Α(&&(&6Θ (Α=+Μ(Α>%Μ( (Η>>?Η+&ϑ(?#(>Σ((+> (ϑ %) Η+)> (Χ%Χ(ΣΗ %& =)( ()ΗΑΑ=?)%+<>=> (7%>> &5ς=( >(?( Η>%=+Ν!!!!! #!!!!!!,[1 Σ (?(/ο.62ϑ=? (Η>%+<Η+).60ϑ=?Α== %+<6Θ (Α=+Μ(Α>%=+Α=(ϑϑ%Α%(+>ΑΗ+> (+#( ϑ= +)ΗΑΑ=?)%+<>=Ν!!!!! #!!!!!!!!!,κ1 /

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16 ! # %& ()%+! # % & ()+,./01+234/5/ /.6/./3:;6<(=> (? %Α&6./ 6/.6..2 (Η)(?Χ%Χ(&6β(& <<(&>> Η>=> (? =)( &> Η> &(Η=+(5)% (+&%=+Η )%&Α?(>% Η>%=+=ϑ > (ϑ %),(6<6/7ϑ%+%>(( ( (+>&=?ϑ%+%>()%ϑϑ(?(+α(ηχχ?= % Η>%=+&1Η?( %Ι( Λ>=& =Σ &% % Η? (Μ( &=ϑηαα?ηαλη+)χ=&&%# Λ (& )(Χ(+)(+Α(6 9; Β %& /& 1 +(01#) + Θ (?(%&+=( ΗΑ>Η+Η Λ>%ΑΗ &= >%=+ϑ=?>?((5)% (+&%=+Η (Η>>?Η+&ϑ(?%+Η#=?( = ( <(= (>?Λ> Η>ΑΗ+#(ΗΧΧ %()>=>?Λ>=ΜΗ %)Η>(Η+ (?%ΑΗ =)( 6Ω=Σ(Μ(?Ν%ϑ=+ Λ Α=+) Α>%=+%+>Σ=)% (+&%=+&%&Α=+&%)(?()ΝΑΗ Α Η>%=+=ϑ&>(Η)Λ5&>Η>(#=?( = ( > (? Η?(&%&>Η+Α(ΑΗ+#( &()Η&Η (>?%Α>=ΜΗ %)Η>(> ( =)( 6γ= +<,..21ΑΗ??%() = >Η+( >(+&%Μ(&> )Λ>=Α= ΧΗ?(> (&>(Η)Λ&>Η>(#=?( = (?(&%&>Η+Α(&ΑΗ Α Η>() &%+< Η+ #(?=ϑ =)( &Ν%+Α )%+<!Η ι& (> =),/ΥΥ31Ν> (Ρ Η+)8ιδ(Η ι&ηχχ?= % Η>( )%Η (>(? (> =),/ΥΥκ1Η+)> ( >%Χ= ( (> =),ς(++(> +,8ΑΝ/Υκ[16Θ (&(?(& >& Σ(?(Α= ΧΗ?()Σ%> + (?%ΑΗ?(& >& &%+<Η 7Μ(?&%=+=ϑ> (ΡΚΟΕ07&= Μ(?6Θ ( >%Χ= ( (> =)ΑΗ+#(?(<Η?)()Η&Η?(ϑ(?(+Α( (> =)Η+)ΗΑΑ?Η>(>=Σ%> %+ ΗΑ %+(Χ?(Α%&%=+6 &% % Η?Α= ΧΗ?%&=+=ϑ+ (?%ΑΗ =)(?(& >&Σ%> ΜΗ (&=ϑ #=?( = (> (? Η?(&%&>Η+Α(ΑΗ Α Η>() &%+<> ( >%Χ= ( (> =)%&Χ?(&(+>()#( =Σ6 Θ %&Α= ΧΗ?%&=+%&Η &(ϑ ΜΗ %)Η>%=+( (?Α%&(%+> Η>%>>(&>&> (Η#% %>Λ=ϑ> (+ (?%ΑΗ (> =)>=)(Η Σ%> > (Α?Μ()Χ%Χ(Η+)<?= >#= +)Η?Λ<(= (>?Λ6 && %+<> ( (Η>>?Η+&ϑ(?=ϑςΩΚ&%&%+&>(Η)Λ5&>Η>(Ν> (>=>Η Η = +>=ϑ (Η> >?Η+&ϑ(??Η>(Χ(? +%> (+<> #(>Σ((+> (ϑ %)Η+)> (<?= +)ΑΗ+#(( Χ?(&&()Η&4!!!!!!!!!,/.1 Θ (#=?( = (?(&%&>Η+Α()(ϑ%+() (?(%+Α )(&> (Α=+Μ(Α>%Μ(?(&%&>Η+Α(#(>Σ((+ > (ϑ %)Η+)> (%++(?&%)(=ϑ> (Χ%Χ(&Ν> (Α=+) Α>%Μ(?(&%&>Η+Α(=ϑ> (Χ%Χ(&ΝΗ+)> ( Α=+) Α>%Μ(?(&%&>Η+Α(=ϑ> (<?= >6_Η (&=ϑ#=?( = (> (? Η?(&%&>Η+Α(ΑΗ+#(ϑ= +) ϑ?= > (+ (?%ΑΗ =)( #Λ ΗΙ%+<Η&>(Η)Λ5&>Η>(ΑΗ Α Η>%=+=ϑ> ( (Η>ϑ ΗΑ?=&& > (#=?( = (ΣΗ Η+)#=?( = (>( Χ(?Η>?(ϑ=?Η<%Μ(+ϑ %)Η+)ϑΗ?ϑ%( )>( Χ(?Η>?( )%ϑϑ(?(+α(6θσ=&%+< (ςωκ&σ%> )%ϑϑ(?(+>#=?( = ()%Η (>(?&Η+)>Σ=)%ϑϑ(?(+><?= > >ΛΧ(& ΗΜ(#((+&> )%()6Θ (#=?( = ()% (+&%=+&Η+)> (? Η Χ?=Χ(?>%(&Η?(& =Σ+%+ ΘΗ# (/6 9+Χ?%+Α%Χ (ΝΗ+ (?%ΑΗ (> =)& = )Χ?=) Α(?(& >&ΗΧΧ?=ΗΑ %+<> ( Η+Η Λ>%ΑΗ ΜΗ (&=ϑα=+) Α>Η+Α(Η&> ( (& %&?(ϑ%+()6 ΑΑ=?)%+< ΛΝ>=Μ(?%ϑΛ> ( =)( Ν /Ζ

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20 ! # %& ()%+! # % & ()+,./01+234/5/ /.6/./3:;6<(=> (? %Α&6./ 6/.6..2 (Η>ϑ (&#(>Σ((+> (>Σ= (<&=ϑ> (Π5> #(6_Η?%Η>%=+&Σ%>?(&Χ(Α>>=ϑ %) Α%?Α Η>%=+?Η>(& ΗΜ(#((+=ϑϑ?> (?%+>(?(&>6 Θ (&(Η&Χ(Α>&=ϑςΩΚ#( ΗΜ%=?Η?(ΧΗ?> Λ=ϑ%+>(?(&>Η&)%ϑϑ(?(+>Η&& Χ>%=+&Η?( Η)(Η#= >> (&(?( Η>%=+& %Χ&%+&% Χ (? =)( &6 <Η%+Ν&= ()%&>%+Α>%=+ΑΗ+#( Η)( #(>Σ((+& =?>Η+) =+<>% (&ΑΗ (#( ΗΜ%=?Η+)> (ϑ= =Σ%+<)%&Α &&%=+%&&(ΧΗ?Η>() ΗΑΑ=?)%+< Λ69+> (&(&> )%(&Η&%+< (ςωκσ%> Η#=?( = ()%Η (>(?=ϑ/ζ. Η+)Η )(Χ> =ϑ/.. Η&#((+&% Η>()6Θ (<?= >> (? Η Α=+) Α>%Μ%>ΛΣΗ&.6[Ζβ: 6ΞΗ+) => (?ΧΗ?Η (>(?&Η?(Η&& =Σ+%+ΘΗ# (/6Θ (&??= +)%+<<?= +)>=Η)%Η (>(?=ϑ2 (>?(& Η&#((+%+Α )()%+> (&% Η>%=+)= Η%+6 Φ98 Ε +5 #)&,1./& >% 2)/&, Θ=%+Μ(&>%<Η>(> (? Η #( ΗΜ%=?=ϑΗςΩΚΗ> =+<>% (&ΑΗ (&%+Η<(+(?%Α Η++(?Σ( ΗΜ( Η)(Η&(?%(&=ϑΑΗ Α Η>%=+&Σ%> &>(Η)Λ5&>Η>(#= +)Η?ΛΑ=+)%>%=+&6Θ (&(Α=+)%>%=+& Η?(Η &=?(Χ?(&(+>Η>%Μ(=ϑΑ=+)%>%=+&Η> =+<>% (&ΑΗ (&Σ (?(&>(Χ?(&Χ=+&(%&#(%+< Α=+&%)(?()69+> (&(ΑΗ Α Η>%=+&> (%+ (>Η+)ϑΗ?5ϑ%( )#= +)Η?Λ>( Χ(?Η>?(&Η+)> ( ϑ %)ϑ =Σ?Η>( ΗΜ(#((+ϑ% ()6 /.Ξ)%ϑϑ(?(+Α(#(>Σ((+%+ (>Η+)ϑΗ?ϑ%( )>( Χ(?Η>?( Η&#((+ΗΧΧ %()Η+)ΑΗ Α Η>%=+& Η)(ϑ=?ϑ %) (Η+Μ( =Α%>%(&%+> (?Η+<(.6 5/6. :&6 ϑ %)Μ( =Α%>Λ=ϑ.63 :&%&> = < >>=#(?(Χ?(&(+>Η>%Μ(=ϑΗΣ( )(&%<+()ςωκ Σ%>?(Η&=+Η# (Χ?(&&?()?=Χ&6/6. :&%&> = < >>=#(>=ΣΗ?)&> ( ΧΧ(? % %>=ϑ Σ Η> ΗΛ#(ϑ= +)%+Χ?ΗΑ>%Α(6Θ %&Μ( =Α%>Λ%&>ΛΧ%ΑΗ =ϑ# % )%+<&Λ&>( &# > ΗΛ?(& > %+ +?(Η&=+Η# (Χ?(&&?()?=Χ&6ε =ΣΜ( =Α%>%(&Η>> ( =Σ(?(+)=ϑ> %&?Η+<(Η?(=ϑ %+>(?(&>Η&> (Λ ΗΛ=ΑΑ?%+&Λ&>( &Σ%> ΜΗ?%Η# (&Χ(()Χ Χ%+<6Θ %& =Σ(? % %> & = )&>%?(& >%+ϑ Λ>?# (+>ϑ =Σ6ΚΜ(+ =Σ(?ϑ =Σ?Η>(&> Η>?(& >%+ Η %+Η? ϑ =Σ ΗΛ=ΑΑ?%+ΜΗ?%Η# (ϑ =Σ&Λ&>( &6Θ (ϑ =Σ?Η>(&Η+)Φ(Λ+= )&δ #(?&Η+) Α=+Μ(Α>%=+Α=(ϑϑ%Α%(+>&> Η>ΗΧΧ Λ=Μ(?> %&Μ( =Α%>Λ?Η+<(Η?(& =Σ+%+ΘΗ# (26 Θ (ϑ %)>( Χ(?Η>?(ΜΗ?%Η>%=+&Η =+<> (>Σ= (<&=ϑ> (Π5> #(Η?(& =Σ+%+ ε%<6//η+)> (Α=??(&Χ=+)%+<>( Χ(?Η>?(Η>> (#=?( = (ΣΗ %+ε%<6/ 6Θ %&#=?( = ( ΣΗ >( Χ(?Η>?( Η&#((+ϑ= +)ϑ?= > (ΗΜ(?Η<(Η?= +)> (Α%?Α ϑ(?(+α(=ϑ> ( #=?( = (Η>Η<%Μ(+)(Χ> 68Μ(? Α =ϑ> (ϑ =Σ?Η>(?Η+<(> (ϑ %)>( Χ(?Η>?( Χ?=ϑ% (&,ε%<6//1η?(ηχχ?= % Η>( Λ %+(Η?Η+)> (ϑ %)>( Χ(?Η>?(Η>> (#=>>= =ϑ> ( #=?( = (%&?(Χ?(&(+>Η>%Μ(=ϑ> ( (Η+6 > =Σ(?ϑ =Σ?Η>(&> (Χ?=ϑ% (%&+=>%Α(Η# Λ+=+5 %+(Η?ΝΧΗ?>%Α Η? ΛΗ>> (#=>>= =ϑ> (Μ( =Α%>Λ?Η+<(,.6 :&16 >> %&ϑ =Σ?Η>(> (?(%& /Υ

21 ! # %& ()%+! # % & ()+,./01+234/5/ /.6/./3:;6<(=> (? %Α&6./ 6/.6..2 Η<?(Η>(?>( Χ(?Η>?(Α Η+<(Η =+<> (Χ%Χ(Σ%> )=Σ+ΣΗ?)ϑ =Σ,> (Χ%Χ(ϑ=? %+<> ( %+ (>1> Η+> (=> (?6 >> ( %< (&>ϑ =Σ?Η>(> (>( Χ(?Η>?(Η>> (#=?( = (ΣΗ,ε%<6/ 61ΜΗ?%(&Μ(?Λ %>> (6 > =Σ(?ϑ =Σ?Η>(&, :&1+=+5 %+(Η?ΜΗ?%Η>%=+=ϑ#=?( = (>( Χ(?Η>?( Σ%> )(Χ> %&+=>%Α(Η# (6Θ (Α=??(&Χ=+)%+< (Η>ϑ (&ΗΑ?=&&> (#=?( = (ΣΗ Η?( & =Σ+%+ε%<6/069+> %&>ΛΧ(=ϑΑΗ Α Η>%=+> ( (Η>ϑ (&Η?()?%Μ(+#Λ> (>( Χ(?Η>?( )%ϑϑ(?(+α(&#(>σ((+> (ϑ %)Η+)> (#=?( = (ΣΗ 6 > = < > (?(%&Η+ΗΧΧ?= % Η>( Λ %+(Η?ΜΗ?%Η>%=+=ϑϑ %)>( Χ(?Η>?(Η> %< (?ϑ =Σ?Η>(&Ν> ( (Η+ϑ %)>( Χ(?Η>?(Η> ΗΧΗ?>%Α Η?)(Χ> %&+(Η? Λ> (&Η (6Ω(+Α(Ν> (ϑ Η =+<> (#=?( = (Η> %< (?ϑ =Σ?Η>(&%&+(Η? ΛΑ=+&>Η+>6 > =Σϑ =Σ?Η>(&> %&%&+=>> (ΑΗ&(Η+)Η+=>%Α(Η# Λ+=+5 %+(Η? Χ?=ϑ% (ΑΗ+#(&((+6 7 (>=> (>( Χ(?Η>?()%ϑϑ(?(+Α(#(>Σ((+> ( ΧΣΗ?)Η+))=Σ+ΣΗ?)ϑ %)%+ Η);ΗΑ(+>Χ%Χ(&Ν&= ( (Η>%&>?Η+&ϑ(??())%?(Α> Λϑ?= =+(Χ%Χ(>=> (=> (?Ν?Η> (?> Η+ > (#=?( = (ΣΗ 6,Θ %&%+>(?5> #( (Η>ϑ %&&= (>% (&?(ϑ(??()>=η&> (η& =?>5Α%?Α %>ι (Η>ϑ 61Θ (%+>(?5> #( (Η>ϑ Α= )#(( Χ(Α>()>=#(Χ?=Χ=?>%=+Η >=> ( >( Χ(?Η>?()%ϑϑ(?(+Α(#(>Σ((+> ( ΧΣΗ?)Η+))=Σ+ΣΗ?)ϑ =Σ%+<ϑ %)&Η>Η<%Μ(+ )(Χ> %+&>(Η)ΛΑ=+)%>%=+&6Θ %&%&?(ϑ (Α>()%+> ( (Η>ϑ (&& =Σ+%+ε%<6/26Θ %&ϑ %&+Η>?Η Λ %< (&>Η>> (>=Χ=ϑ> (#=?( = (Σ (?(> %&ϑ %)>( Χ(?Η>?()%ϑϑ(?(+Α(%& <?(Η>(&>Η+) =Σ(&>Η>> (#=>>= 6ε%<6//& =Σ()> (<?(Η>(&>>( Χ(?Η>?()%ϑϑ(?(+Α(& +(Η?> (>=Χ=ϑ> (#=?( = (Η>> ( =Σ(&>ϑ =Σ?Η>(6Θ (%+>(?5> #(ϑ %&ΝΗΑΑ=?)%+< ΛΝ & =Σ+%+ε%<6/2>=#( %< (&>Η>> ( =Σ(&>ϑ =Σ?Η>(6 >> ( %< (&>ϑ =Σ?Η>(> %&ϑ?(χ?(&(+>&ηχχ?= % Η>( Λ ρ=ϑ> (>=>Η #=?( = ( (Η>>?Η+&ϑ(?Η+)Η>> ( =Σ(&>ϑ =Σ?Η>(> %&%&%+Α?(Η&()>=/.ρ6 Ε= (=#&(?ΜΗ>%=+&?(<Η?)%+< =)( %+<Χ?ΗΑ>%Α(ΑΗ+#( Η)(#Η&()=+> (&(?(& >&6Ο=)( &> Η>)=+=>%+Α )(Η+( Χ %Α%>?(Χ?(&(+>Η>%=+=ϑ> (Α= Χ=+(+>&=ϑ> ( #=?( = (# >)(ϑ%+(> (?( Η>%=+& %Χ#(>Σ((+> (ϑ %)>( Χ(?Η>?(Η+)#=?( = (ΣΗ >( Χ(?Η>?(#ΛΗ&%+< (> (? Η?(&%&>Η+Α(,(6<6<5ϑ +Α>%=+ =)( && Α Η&> Η>%+ Κ+(?<Λ! &,ε%& (? +,8Α..31Ν=ϑ>(+Η&& (> (ϑ %)>( Χ(?Η>?(>=#(> ( (Η+=ϑ > (%+ (>Η+)= > (>ΜΗ (&Η+)> Η>Α=+)%>%=+&Η?(Α=+&>Η+>Η =+<> (#=?( = (6Θ ( %+(Η?Η+)&Λ (>?%ΑΗ >( Χ(?Η>?(Χ?=ϑ% (Η+)> (Α=+&>Η+>#=?( = (ΣΗ Α=+)%>%=+& & =Σ+%+> (?(& >&ϑ=? %< (?ϑ =Σ?Η>(&& <<(&>> Η>> %&%&Η?(Η&=+Η# (Η&& Χ>%=+6.

22 ! # %& ()%+! # % & ()+,./01+234/5/ /.6/./3:;6<(=> (? %Α&6./ 6/.6..2 > =Σ(?ϑ =Σ?Η>(&> %&%&+=>> (ΑΗ&(Η+)Η+=> (? =)( %+<ΗΧΧ?=ΗΑ & = )Χ?=#Η# Λ #(Α=+&%)(?()6 9+Η>Σ=5)% (+&%=+Η + (?%ΑΗ =)( Νϑ=?( Η Χ (> Η>=ϑγΗΜ >?Ι +,8Α,/ΥΥΥ1Ν&= (Η&& Χ>%=+ Η&>=#( Η)(Η#= >> (>( Χ(?Η>?(#= +)Η?ΛΑ=+)%>%=+ ΗΧΧ %()Η>(ΗΑ Χ%Χ(6Θ (&Η ( (Η+>( Χ(?Η>?(%&ϑ= +)Σ (> (?> (Χ%Χ( >( Χ(?Η>?(&Η?(Η&& ()>=#(> (%+ (>Η+)= > (>>( Χ(?Η>?(&Ν=?Σ (> (?> (ΛΗ?( #=> Η&& ()>=#(Η>> ( (Η+Α=+)%>%=+6Ω=Σ(Μ(?Ν=+(Η&& Χ>%=+Σ%?(& >%+Η+ =Μ(?5Χ?()%Α>%=+=ϑ> (%+>(?5> #(ϑ Η+)> (=> (?Η (?=%+>(?5> #(ϑ 6δ(%> (?=ϑ > (&(Η&& Χ>%=+&&(( &ΗΧΧ?=Χ?%Η>(%+ %< >=ϑ> (?(& >&?(Χ=?>()Η#=Μ(68+( %+>(?Χ?(>Η>%=+=ϑ> ( %+(Η?Χ?=ϑ% (&& =Σ+%+&= (?(& >&Σ= )#(> Η>> ( >( Χ(?Η>?(#= +)Η?ΛΑ=+)%>%=+&ΗΧΧ %()Η>> (Χ%Χ(&& = )Α=??(&Χ=+)>=> Η> Η ϑ ΣΗΛΗ =+<> (#=?( = (6Θ %&Σ= )#(( %ΜΗ (+>>=ση+)τ=ϑ> ()%ϑϑ(?(+α(#(>σ((+ > (%+ (>Η+)= > (>>( Χ(?Η>?(&?( Η>%Μ(>=> (%+ (>6 <Η%+Ν> %& ΗΛ+=>#(ΗΧΧ?=Χ?%Η>( Η> =Σϑ =Σ?Η>(&6 Φ9; Γ %# #)&,1./& >% 2)/&, 9> Η&Η?(Η)Λ#((+& =Σ+> Η>ΝΗ>& =?>>% (&ΑΗ (&Ν> ()Λ+Η %Α?(&Χ=+&(=ϑ> (<?= > Η+)> (>?Η+&Χ=?>=ϑϑ %)Η?= +)> (Χ%Χ(&ΑΗ+ ΗΜ(Η&%<+%ϑ%ΑΗ+>(ϑϑ(Α>=+> (?(&Χ=+&( =ϑ > ( (Η>( Α Η+<(?6 Ε =?> >% (&ΑΗ ( ΜΗ?%Η>%=+&%+ >( Χ(?Η>?( Η+) (Η> ϑ Χ?=ϑ% ( ΗΜ(#((+&> )%()#Λ ΗΙ%+< >?Η+&%(+> ΑΗ Α Η>%=+& Η+) ΗΧΧ Λ%+< Η&>(Χ#= +)Η?Λ Α=+)%>%=+>=> (%+ (>>( Χ(?Η>?(69+> (&(ΑΗ Α Η>%=+&> (%+ (>%&%+Α?(Η&()/.ΞΗ#=Μ( > (%+%>%Η &>Η>(Η+)?(& >&Η?(Χ?(&(+>()ϑ=?Η?Η+<(=ϑ+= %+Η Α%?Α Η>%+<ϑ %)>?Η+&%> >% (& Χ >= 06.6 &>(Χ?(&Χ=+&(#= +)Η?Λ Α=+)%>%=+%& =ϑ Χ?ΗΑ>%ΑΗ %+>(?(&>#(ΑΗ &( Η+Λ&Λ&>( &Η?(Α=+>?= ()#Λ>?+%+<> ( (Η>Χ Χ=+Η+)=ϑϑ%+>(? %>>(+> Λ6 Θ (>( Χ(?Η>?(Χ?=ϑ% (&ΜΗ?ΛΣ%> >% (# >Η &=Σ%> ϑ %)Α%?Α Η>%+<Μ( =Α%>Λ=? ϑ =Σ?Η>(6Φ(& >&ϑ=?ϑ %)Μ( =Α%>%(&=ϑ/6. :&Ν.63 :&Η+).6 :&Η?(& =Σ+%+ε%<&6/Ζ ϕ/[?(&χ(α>%μ( Λ69+Η ΑΗ&(&> (ϑ %)>( Χ(?Η>?(Χ?=ϑ% (Η>> ((Η? %(&>>% (&,ςο.601 Α Η+<(& Α =?(Ν Η+)%+ Η +=>%Α(Η# Λ +=+5 %+(Η? Η++(?Ν%+ > ()=Σ+ΣΗ?) ϑ =Σ%+< > #(6 & >% ( Χ?=<?(&&(&,>=ΣΗ?)& ςο01 > ( ϑ %) >( Χ(?Η>?( Χ?=ϑ% ( ΑΗ+#(&((+ >= )(Μ( =Χ%+>=Η =?( %+(Η?Η+)( Η Λ)%Μ%)()ϑ=? 69+> (ΑΗ&(Σ%> =Σϑ %)Μ( =Α%>Λ,ε%<6/[1> (+=+5 %+(Η?+Η>?(=ϑ> (>( Χ(?Η>?(Χ?=ϑ% (Χ(?&%&>&6 /

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