ΑΜΦΙΚΟΙΛΙΑΚΗ ΒΗΜΑΤΟΔΟΤΗΣΗ

ΠΑΝΕΛΛΗΝΙΑ ΣΕΜΙΝΑΡΙΑ ΟΜΑΔΩΝ ΕΡΓΑΣΙΑΣ 2015 ΟΜΑΔΑ ΕΡΓΑΣΙΑΣ ΚΑΡΔΙΑΚΗΣ ΑΝΕΠΑΡΚΕΙΑΣ Από τη βασική έρευνα στην κλινική πράξη ΑΜΦΙΚΟΙΛΙΑΚΗ ΒΗΜΑΤΟΔΟΤΗΣΗ Ξυδώνας Σωτήριος, MD, FESC Καρδιολογικό Τµήµα, Γ.Ν.Α. «Ο Ευαγγελισµός»

Δεν υπάρχει σύγκρουση συµφερόντων µε τις χορηγούς εταιρείες

Hemodynamic parameters COMPANION study. N Engl J Med 2004;350:2140-50.

Hemodynamic parameters Europace 2015 Feb 06; [EPub Ahead of Print],

Mechano - Energetic efficiency Circulation 2000;102:3053-3059.

CRT: Από τη βασική έρευνα στην κλινική πράξη! Molecular Polarization! Electrophysiological changes! Regional Transcriptome! Proteomics Mitochondria! ECG Activation Maps

Molecular Polarization Canine model of cardiac dyssynchrony and resynchronization Circulation 2009;119:1231 1240.

Molecular Polarization CRT increases levels of endogenous inotrope APELIN Eur J Heart Fail 2007;9:306 309.

Molecular Polarization CRT and Inflammation Pacing Clin Electrophysiol. 2006;29:753 758.

Molecular Polarization CRT - Remodeling - Tenascin-C and MMP-9 Eur J Heart Fail. 2007;9:1058 1063.

Molecular Polarization Circulation. 2003;108:929-932.

Molecular Polarization CRT reversal of global Apoptosis and Regional Stress Kinase Activation Circulation. 2008;117:1369 1377.

APD and CRT Electrophysiological Changes APD in LV myocytes from control, DHF, and CRT hearts. A Representative superimposed APs recorded at pacing CL of 0.5, 1.0, 2.0, and 4.0s B Relationship between pacing CL and APD at 90% recovery (APD90) from anterior and lateral myocytes in each group. All data were obtained during pacing at 0.25 Hz. P0.05 vs control; #P0.05 vs DHF. ANT or A indicates anterior; LTR or L, lateral.

Electrophysiological Changes TNF- α prolongs APD Am J Physiol Heart Circ Physiol 2007;293:H238 H245.

Electrophysiological Changes TNF-α reduces I to current Am J Physiol Heart Circ Physiol 2007;293:H238 H245.

Electrophysiological Changes Oxidative stress, APD increase and EADs Circ Res. 2009;104:79-86.

Electrophysiological Changes Oxidative stress, CaMKII, I Na increase, APD prolongation, Arrhythmias J Clin Invest. 2006;116:3127 3138.

Electrophysiological Changes CRT decreases EADs Circulation. 2009;119:1220 1230.

Electrophysiological Changes CRT restores I K1, I kr, I ks, but not I to Circulation. 2009;119:1220 1230.

CRT restores I K1, I kr, I ks, but not I to Electrophysiological Changes DADs DADs Circulation. 2009;119:1220 1230.

Electrophysiological Changes CRT restores I CaT and I CaL

Regional Transcriptome Trancriptome Circ Cardiovasc Genet. 2009;2:371-378.

Regional Transcriptome CRT restores homogeneous glucose metabolism J Am Coll Cardiol 2003;41:1523 8.

Regional Transcriptome CRT improves G-protein signaling Summarized data for up-regulation and down-regulation of the regulator of G-protein signaling (RGS) proteins by CRT Circulation. 2009;119:1231 1240.

Proteomics Mitochondria

CRT improves Mitochondria Proteomics Circ Cardiovasc Genet. 2010;3:78-87

Myocardial Wall Motion J Am Coll Cardiol 2007;50:243 52.

Survival and CMR-TSI J Am Coll Cardiol 2007;50:243 52.

Main CRT studies and QRS morphology Heart Rhythm, http://dx.doi.org/10.1016/j.hrthm.2015.01.023

Propagation Mapping ECG Activation Maps in press Heart Rhythm 2015;0:1 10

Electrical dyssynchrony parameters in press Heart Rhythm 2015;0:1 10

ECG Activation Maps CircAdapt model Europace 2014;16:iv62 iv68.

Effects of CRT on SV and resynchronization of viable myocardial tissue Europace 2014;16:iv62 iv68.

WiCS-LV technology. Myocarditis (WHO/ISFC) Circulation1996;93:841 842. Europace 2013;15:1191 1197

Europace 2014:16:681 688.

NYHA, LVEF, LVEDV, LVESV Europace 2013;15:1191 1197

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